Quinolines and derivatives
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000348888 RESIQUIMOD 10MM 1ML
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5000348748 ETHYLHYDROCUPREINE 50MG
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eMolecules EMOLECULES INC
5000473908 2-METHOXYPYRIDINE-4-CARB 100MG
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eMolecules EMOLECULES INC
5000491494 METHYL 2-QUINOLIN-6-YLAC 10G
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Apexbio Technology LLC β-Naphthoflavone 6051-87-2 200mg
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-Naphthoflavone (CAS 6051-87-2) also known as 5 6-benzoflavone is a small molecule that acts as a potent agonist of the aryl hydrocarbon receptor (AhR) Activation of AhR by -naphthoflavone upregulates the expression of metabolizing enzymes including multiple cytochrome P450 isoforms (CYPs) and uridine 5 -diphospho-glucuronosyltransferases (UGTs) This compound is widely utilized in biomedical research to investigate xenobiotic metabolism enzyme induction and the regulation of detoxification pathways Additionally it has been studied for its potential role in chemoprevention due to its modulatory effects on metabolic enzymes
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000348427 SITAGLIPTIN 200MG
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Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 5mg, CAS: 104821-25-2.
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Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer
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Sigma Aldrich Fine Chemicals Biosciences Metergoline | 17692-51-2 | MFCD00153829 | 500MG
Metergoline | Mol Wt: 403.52 | 17692-51-2 | MFCD00153829 | 500MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000409099 PIPERIDOLATE 200MG
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Accela Chembio Inc 5-aminoisoquinoline | 25g | 1125-60-6 | MFCD00006907 | 98% | Shelf Life: 1980 Days | Light Sensitive/+4
5-aminoisoquinoline | 25g | 1125-60-6 | MFCD00006907 | 98% | Shelf Life: 1980 Days | Light Sensitive/+4
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000404567 2 8-QUINOLINEDIOL 10G
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Apexbio Technology LLC PCI-24781 (CRA-024781) 783355-60-2 200mg
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PCI-24781 (CRA-024781 CAS 783355-60-2) is a histone deacetylase (HDAC) inhibitor targeting HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 with reported Ki values of 7 19 8 2 17 280 and 24 nM respectively HDAC enzymes catalyze the removal of acetyl groups from lysine residues on histone proteins thereby regulating chromatin structure and gene expression PCI-24781 induces dose-dependent hyperacetylation of histones and tubulin in human cancer cells (HCT116 DLD-1) leading to apoptosis via p21 upregulation PARP cleavage and H2AX accumulation PCI-24781 demonstrates antitumor activity against multiple tumor cell lines and in xenograft models highlighting its utility for oncology research
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Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 200mg
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NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
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Apexbio Technology LLC Panobinostat (LBH589) 404950-80-7 200mg
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Panobinostat (LBH589) is a histone deacetylase (HDAC) inhibitor targeting class I II and IV HDAC enzymes regulating gene expression through histone hyperacetylation In vitro studies indicate panobinostat induces apoptosis and growth arrest in Ph-negative acute lymphoblastic leukemia (ALL) cell lines T-cell (MOLT-4) and pre-B cell (Reh) via caspase activation PARP cleavage and downregulation of c-Myc accompanied by H3K9 and H4K8 hyperacetylation and elevation of cell-cycle regulators (p21 p27) Panobinostat has shown anti-proliferative effects in various cancer models including cutaneous T-cell lymphoma and multiple myeloma (IC50 5-30 nM) and serves as a research tool in studies assessing epigenetic regulation and tumor biology
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eMolecules EMOLECULES INC
5000490373 TERT-BUTYL 4-AMINO-4-CARBA 10G
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